Perampanel: Another Choice for Patients with Idiopathic Generalized Epilepsy who Have Tonic–Clonic Seizures

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Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy

OBJECTIVE To assess efficacy and safety of adjunctive perampanel in patients with drug-resistant, primary generalized tonic-clonic (PGTC) seizures in idiopathic generalized epilepsy (IGE). METHODS In this multicenter, double-blind study (ClinicalTrials.gov identifier: NCT01393743; funded by Eisai Inc.), patients 12 years or older with PGTC seizures and IGE were randomized to placebo or peramp...

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Although there is increasing evidence suggesting that there may be subtle abnormalities in idiopathic generalized epilepsy (IGE) patients using modern neuroimaging techniques, most of these previous studies focused on the brain grey matter, leaving the underlying white matter abnormalities in IGE largely unknown, which baffles the treatment as well as the understanding of IGE. In this work, we ...

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ژورنال

عنوان ژورنال: Epilepsy Currents

سال: 2016

ISSN: 1535-7597,1535-7511

DOI: 10.5698/1535-7597-16.1.27